{HandVoxNet}: {D}eep Voxel-Based Network for {3D} Hand Shape and Pose Estimation from a Single Depth Map

3D hand shape and pose estimation from a single depth map is a new and challenging computer vision problem with many applications. The state-of-the-art methods directly regress 3D hand meshes from 2D depth images via 2D convolutional neural networks, which leads to artefacts in the estimations due to perspective distortions in the images. In contrast, we propose a novel architecture with 3D convolutions trained in a weakly-supervised manner. The input to our method is a 3D voxelized depth map, and we rely on two hand shape representations. The first one is the 3D voxelized grid of the shape which is accurate but does not preserve the mesh topology and the number of mesh vertices. The second representation is the 3D hand surface which is less accurate but does not suffer from the limitations of the first representation. We combine the advantages of these two representations by registering the hand surface to the voxelized hand shape. In the extensive experiments, the proposed approach improves over the state of the art by 47.8% on the SynHand5M dataset. Moreover, our augmentation policy for voxelized depth maps further enhances the accuracy of 3D hand pose estimation on real data. Our method produces visually more reasonable and realistic hand shapes on NYU and BigHand2.2M datasets compared to the existing approaches

Real-time marker-less multi-person 3D pose estimation in RGB-Depth camera networks

This paper proposes a novel system to estimate and track the 3D poses of multiple persons in calibrated RGB-Depth camera networks. The multi-view 3D pose of each person is computed by a central node which receives the single-view outcomes from each camera of the network. Each single-view outcome is computed by using a CNN for 2D pose estimation and extending the resulting skeletons to 3D by means of the sensor depth. The proposed system is marker-less, multi-person, independent of background and does not make any assumption on people appearance and initial pose. The system provides real-time outcomes, thus being perfectly suited for applications requiring user interaction. Experimental results show the effectiveness of this work with respect to a baseline multi-view approach in different scenarios. To foster research and applications based on this work, we released the source code in OpenPTrack, an open source project for RGB-D people tracking.Comment: Submitted to the 2018 IEEE International Conference on Robotics and Automatio

Immunomodulatory effects of tigecycline in Balb/c mice

Tigecycline is a glycylcycline antibiotic approved by the FDA for the treatment of complicated infections. Despite its effectiveness, the FDA announced a warning of increasing mortality associated with its use. There is, however, no clear explanation for this side effect. Previous reports found a possible effect of tigecycline on leukocyte proliferation and proinflammatory cytokine release. We therefore investigated the effect of tigecycline on the immune components and response in Balb/c mice in vivo and in vitro. It was found that tigecycline enhanced lymphocyte proliferation and significantly increased cellular infiltration within the footpad, as based on DTH testing, but reduced the hemagglutination titer. In splenocyte cultures, tigecycline suppressed splenocyte proliferation with IC50 3–5 mol L–1, significantly increased IL-2 secretion and reduced IL-17 secretion in a dose dependent mode. In conclusion, tigecycline is safe at therapeutic and sub-therapeutic doses, but it could still have an immunomodulatory effect at higher doses. Use of higher doses of tigecycline requires further investigation

Association between age at disease onset of anti-neutrophil cytoplasmic antibody-associated vasculitis and clinical presentation and short-term outcomes

Objectives: ANCA-associated vasculitis (AAV) can affect all age groups. We aimed to show that differences in disease presentation and 6 month outcome between younger- A nd older-onset patients are still incompletely understood. Methods: We included patients enrolled in the Diagnostic and Classification Criteria for Primary Systemic Vasculitis (DCVAS) study between October 2010 and January 2017 with a diagnosis of AAV. We divided the population according to age at diagnosis: <65 years or ≥65 years. We adjusted associations for the type of AAV and the type of ANCA (anti-MPO, anti-PR3 or negative). Results: A total of 1338 patients with AAV were included: 66% had disease onset at <65 years of age [female 50%; mean age 48.4 years (s.d. 12.6)] and 34% had disease onset at ≥65 years [female 54%; mean age 73.6 years (s.d. 6)]. ANCA (MPO) positivity was more frequent in the older group (48% vs 27%; P = 0.001). Younger patients had higher rates of musculoskeletal, cutaneous and ENT manifestations compared with older patients. Systemic, neurologic,cardiovascular involvement and worsening renal function were more frequent in the older-onset group. Damage accrual, measured with the Vasculitis Damage Index (VDI), was significantly higher in older patients, 12% of whom had a 6 month VDI ≥5, compared with 7% of younger patients (P = 0.01). Older age was an independent risk factor for early death within 6 months from diagnosis [hazard ratio 2.06 (95% CI 1.07, 3.97); P = 0.03]. Conclusion: Within 6 months of diagnosis of AAV, patients >65 years of age display a different pattern of organ involvement and an increased risk of significant damage and mortality compared with younger patients

Outdoor Human Motion Capture by Simultaneous Optimization of Pose and Camera Parameters

We present a method for capturing the skeletal motions of humans using a sparse set of potentially moving cameras in an uncontrolled environment. Our approach is able to track multiple people even in front of cluttered and non-static backgrounds, and unsynchronized cameras with varying image quality and frame rate. We completely rely on optical information and do not make use of additional sensor information (e.g. depth images or inertial sensors). Our algorithm simultaneously reconstructs the skeletal pose parameters of multiple performers and the motion of each camera. This is facilitated by a new energy functional that captures the alignment of the model and the camera positions with the input videos in an analytic way. The approach can be adopted in many practical applications to replace the complex and expensive motion capture studios with few consumer-grade cameras even in uncontrolled outdoor scenes. We demonstrate this based on challenging multi-view video sequences that are captured with unsynchronized and moving (e.g. mobile-phone or GoPro) cameras

Feature-based multi-video synchronization with subframe accuracy

We present a novel algorithm for temporally synchronizing multiple videos capturing the same dynamic scene. Our algorithm relies on general image features and it does not require explicitly tracking any specific object, making it applicable to general scenes with complex motion. This is facilitated by our new trajectory filtering and matching schemes that correctly identifies matching pairs of trajectories (inliers) from a large set of potential candidate matches, of which many are outliers. We find globally optimal synchronization parameters by using a stable RANSAC-based optimization approach. For multi-video synchronization, the algorithm identifies an informative subset of video pairs which prevents the RANSAC algorithm from being biased by outliers. Experiments on two-camera and multi-camera synchronization demonstrate the performance of our algorithm. ?? 2012 Springer-Verlag

Immunomodulatory Effects of Tigecycline in Balb/C Mice

Tigecycline is a glycylcycline antibiotic approved by the FDA for the treatment of complicated infections. Despite its effectiveness, the FDA announced a warning of increasing mortality associated with its use. There is, however, no clear explanation for this side effect. Previous reports found a possible effect of tigecycline on leukocyte proliferation and proinflammatory cytokine release. We t herefore i nvestigated the effect of tigecycline on the immune components and response in Balb/c mice in vivo and in vitro. It was found that tigecycline enhanced lymphocyte proliferation and significantly increased cellular infiltration within the footpad, as based on DTH testing, but reduced the hemagglutination titer. In splenocyte cultures, tigecycline suppressed splenocyte proliferation with IC50 3-5 mmol L-1, significantly increased IL-2 secretion and reduced IL-17 secretion in a dose dependent mode. In conclusion, tigecycline is safe at therapeutic and sub-therapeutic doses, but it could still have an immunomodulatory effect at higher doses. Use of higher doses of tigecycline requires further investigation